Cefotetan disodium is a semi-synthetic β-lactam antibiotic that is classified as a second generation cephalosporin. Cefotetan disodium effects a broad range of gram positive and gram negative bacteria. It has also displayed a significant degree of bactericidal activity towards aerobic and anaerobic bacteria.

Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.

Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Cefotiam is a second generation cephalosporin antibiotic effective against gram-negative and gram-positive bacteria. However, it is not effective against Pseudomonas aeruginosa. Cefotiam has been used as a prophylactic antibiotic against methicillin-resistant Staphylococcus aureus or MRSA. It is soluble in aqueous solution.

Cefoxitin is a cephamycin antibiotic grouped with the second generation cephalosporins. It is effective against gram-positive and gram-negative bacteria and is especially effective against anaerobic bacteria. Cefoxitin is resistant to degradation by β-lactamases.

Cefozopran is a fourth generation cephalosporin antibiotic effective against a variety of gram-negative and gram-positive organisms, including Pseudomonas aeruginosa. It is effective against MRSA when combined with antibiotics such as vancomycin and teicoplanin. Cefozopran HCl is soluble in DMSO and water.

Cefpirome is a fourth generation cephalosporin antibiotic targeting gram-positive and gram-negative bacteria. Is it not effective against many Bacteroides, Enterococci, and Haemophili species due to the resistance they have developed.

Cefpirome is a fourth generation cephalosporin antibiotic targeting gram-positive and gram-negative bacteria. Is it not effective against many Bacteroides, Enterococci, and Haemophili species due to the resistance they have developed. Cefpirome sulfate with sodium carbonate is a mixture of cefpirome sulfate and anhydrous sodium carbonate and is commonly used for the stabilization of pH.

Cefpodoxime proxetil is a third generation cephalosporin antibiotic targeting a wide variety of gram-negative and gram-positive organisms, especially those responsible for otitis media and pharyngitis. It is an ester prodrug of the free acid metabolite cefpodoxime.

Cefpodoxime sodium is a third generation cephalosporin antibiotic. It targets gram-positive and gram-negative bacteria, especially those responsible for otitis media and pharyngitis.

Cefpodoxime is a third generation cephalosporin antibiotic. It targets gram-positive and gram-negative bacteria, especially those responsible for otitis media and pharyngitis.

Cefprozil is a second generation cephalosporin antibiotic targeting gram-negative and gram-positive bacteria. It shows some resistance to β-lactamase activity.

Cefradine (also known as cephradine) is a first generation cephalosporin antibiotic similar to cephalexin. It targets both gram-negative and gram-positive bacteria. In addition, cefradine has been used to study penicillin binding proteins, especially PBP3.

Cefsulodin is a third generation cephalosporin antibiotic used as a selective agent in isolation media such as Yersinia Selective Agar, Columbia Blood Agar, Salmonella Chromogenic Agar, and CIN Agar. It is mildly effective against gram-positive and gram-negative bacteria, but exhibits greater efficacy against Pseudomonas aeruginosa. In addition to its antimicrobial properties, cefsulodin is a substrate for the rat Oatp1a4 transporter.