Anti-Fungal

Gold Biotechnology is committed to providing the best quality anti-fungal agents and fungicides for your laboratory research needs. Our antifungal reagents are perfectly suited for research in clinical microbiology, plant biology or mammalian cell culture. GoldBio antifungals are used in research and diagnostic applications in industry and academic research labs and have consistent lot-to-lot consistency to ensure the best research results and optimized efficiency.
Showing 1-20 of 25 items.

5-Fluorocytosine

Catalog ID Size Pricing
F-500-1 1 g $ 153.00
F-500-5 5 g $ 344.00

Description

5-Fluorocytosine is a fluorinated cytosine analog and antifungal agent. 5-fluorocytosine becomes 5-fluorouracil and is then incorporated into RNA, causing miscoding and inhibition of DNA synthesis. It is effective against Candida and Cryptococcus species and can be used as a negative selection agent in transgenic plants.

Product Specifications

Catalog ID F-500
CAS # 2022-85-7
MW 129.09 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at 4°C. Protect from light.
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F-500-1 1 g $ 153.00
F-500-5 5 g $ 344.00

Ampho99

Catalog ID Size Pricing
A-562-250 250 mg $ 58.00
A-562-500 500 mg $ 104.00
A-562-1 1 g $ 184.00

Description

Ampho99 is the purest form of amphotericin B available and should be used for the most sensitive applications. In general, GoldBio’s USP Grade amphotericin B will not adversely affect your cells and is suitable for most experiments.

Amphotericin B is a polyene antifungal isolated from Streptomyces species. While it has been suggested that Amphotericin B interacts with ergosterol of the fungal cell membrane leading to an altered cell membrane permeability and death, more recent studies show that the mechanism behind amphotericin B’s fungicidal activity is more complex. It is most effective against fungi and yeast and is often used against opportunistic fungal infections and leishmaniasis. Additionally, amphotericin B can be used to prevent growth of F. oxysporum in chickpea and P. triticina in wheat. It is soluble in acidic and basic conditions.

Product Specifications

Catalog ID A-562
CAS # 1397-89-3
MW 924.08 g/mol
Storage/Handling Store at 4°C.
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A-562-250 250 mg $ 58.00
A-562-500 500 mg $ 104.00
A-562-1 1 g $ 184.00

Amphotericin B, Solubilized

Catalog ID Size Pricing
A-561-250 250 mg $ 98.00
A-561-500 500 mg $ 187.00
A-561-1 1 g $ 347.00

Description

Solubilized amphotericin B is a mixture of 45% amphotericin B, 37% sodium deoxycholate, and 18% phosphate buffer.

Amphotericin B is a polyene antifungal isolated from Streptomyces species. While it has been suggested that Amphotericin B interacts with ergosterol of the fungal cell membrane leading to an altered cell membrane permeability and death, more recent studies show that the mechanism behind amphotericin B’s fungicidal activity is more complex. It is most effective against fungi and yeast and is often used against opportunistic fungal infections and leishmaniasis. Additionally, amphotericin B can be used to prevent growth of F. oxysporum in chickpea and P. triticina in wheat.

Product Specifications

Catalog ID A-561
CAS # 1397-89-3
MW 924.08 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at 4°C.
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A-561-250 250 mg $ 98.00
A-561-500 500 mg $ 187.00
A-561-1 1 g $ 347.00

Amphotericin B, USP Grade

Catalog ID Size Pricing
A-560-250 250 mg $ 51.00
A-560-500 500 mg $ 93.00
A-560-1 1 g $ 141.00
A-560-5 5 g $ 532.00

Description

Amphotericin B is a polyene antifungal isolated from Streptomyces species. While it has been suggested that Amphotericin B interacts with ergosterol of the fungal cell membrane leading to an altered cell membrane permeability and death, more recent studies show that the mechanism behind amphotericin B’s fungicidal activity is more complex. It is most effective against fungi and yeast and is often used against opportunistic fungal infections and leishmaniasis. Additionally, amphotericin B can be used to prevent growth of F. oxysporum in chickpea and P. triticina in wheat.

Product Specifications

Catalog ID A-560
CAS # 1397-89-3
MW 924.08 g/mol
Storage/Handling Store desiccated at 4°C. Protect from light.
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A-560-250 250 mg $ 51.00
A-560-500 500 mg $ 93.00
A-560-1 1 g $ 141.00
A-560-5 5 g $ 532.00

Anisomycin

Catalog ID Size Pricing
A-580-25 25 mg $ 61.00
A-580-100 100 mg $ 200.00

Description

Anisomycin is an antifungal produced by Streptomyces griseolus. It functions by inhibiting protein synthesis in certain eukaryotic cells. Anisomycin inhibits peptidyl transferase activity in the 60s subunit of the 80s ribosome.

Anisomycin has been shown to promote apoptosis in promyelocytic leukemia cells, Jurkat cells, ventricular monocytes, and colon adenocarcinoma cells. Additionally, anisomycin is a JNK agonist and activates MAP kinases. It is a useful antiprotozoal agent.

Product Specifications

Catalog ID A-580
CAS # 22862-76-6
MW 265.30 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at 4°C.
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A-580-25 25 mg $ 61.00
A-580-100 100 mg $ 200.00

Caspofungin Acetate

Catalog ID Size Pricing
C-520-10 10 mg $ 144.00

Description

Caspofungin acetate is an echinocandin antifungal targeting the fungal cell membrane and inhibiting β(1,3)-D-Glucan synthase, a component necessary for cell wall synthesis. Caspofungin acetate is useful against Aspergillus and Candida species.

Product Specifications

Catalog ID C-520
CAS # 179463-17-3
MW 1213.42 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at -80°C.
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C-520-10 10 mg $ 144.00

Cecropin P1, porcine

Catalog ID Size Pricing
C-241-1 1 mg $ 303.00

Description

Cecropin P1, porcine is a 31 amino acid antibacterial protein that can be isolated from pigs. Cecropin P1 is used as an antibacterial, antifungal and anti-cancer compound. The wide ranging effects of cecropin P1 are properties of its amphipathic N-terminal, lipophilic C-terminal and alpha helical structure. With these structural characteristics, cecropin P1 can bind to the membranes of pathogens and cancerous cells. Cecropin P1 then is inserted into the membrane of the respective cell and disrupts lipid bilayer cohesion, causing rapid membrane degradation and cell lysis.

Product Specifications

Catalog ID C-241
CAS # 125667-96-1
MW 3.34 kDa
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C-241-1 1 mg $ 303.00

Cetylpyridinium chloride

Catalog ID Size Pricing
C-120-100 100 g $ 53.00

Description

Cetylpyridinium chloride is a cationic quaternary ammonium compound that has been used to eliminate oral pathogens. It has shown a high degree of efficacy towards gram-positive, gram-negative bacteria and some pathogenic fungi.

Cetylpyridinium chloride functions as a surfactant, reducing the surface tension between pathogenic membranes and their environments. Greater interaction between the membrane and environment disrupts the cell membrane and osmoregulation. Compromising the membrane ultimately results in cell death.

Product Specifications

Catalog ID C-120
CAS # 6004-24-6
MW 358.00 g/mol
UN Number 2811
Item Class 6.1
Group Number II
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C-120-100 100 g $ 53.00

Chlorhexidine

Catalog ID Size Pricing
C-615-1 1 g $ 93.00
C-615-5 5 g $ 369.00

Description

Chlorhexidine is a cationic polybisbiguanide used as a detergent as well as a bactericidal, anti-viral and antifungal agent. It has been used against an array of oral pathogens, with a high effectiveness toward gram-negative bacteria.

Chlorhexidine, when placed into physiological pH, dissociates into its cationic form and binds to the negatively charged bacterial wall. This binding will cause cytosolic leakage at low concentrations and lytic effects at high chlorohexidine concentrations. However, chlorhexidine activity can be halted upon interaction with anionic compounds.

Product Specifications

Catalog ID C-615
CAS # 55-56-1
MW 505.45 g/mol
UN Number 3077
Item Class 9
Group Number III
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C-615-1 1 g $ 93.00
C-615-5 5 g $ 369.00

Chlorhexidine diacetate salt

Catalog ID Size Pricing
C-250-25 25 g $ 187.00

Description

Chlorhexidine diacetate salt is a diacetate derivative of a cationic polybisbiguanide that has bactericidal, anti-fungal and anti-viral activity. It has also been used for in vivo pharmacokinetic research to investigate drug release rates.

Chlorhexidine, when placed into physiological pH, dissociates into its cationic form and binds to the negatively charged bacterial wall. This binding will cause cytosolic leakage at low concentrations and lytic effects at high chlorohexidine concentrations. However, chlorhexidine activity can be halted upon interaction with anionic compounds.

Product Specifications

Catalog ID C-250
CAS # 56-95-1
MW 625.55 g/mol
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C-250-25 25 g $ 187.00

Chlorhexidine HCl

Catalog ID Size Pricing
C-725-5 5 g $ 53.00
C-725-25 25 g $ 192.00

Description

Chlorhexidine HCl is the cationic salt form of chlorhexidine, a bactericidal detergent. Chlorhexidine HCl has strong bactericidal activity and is used for in vitro bactericidal assays as a positive control.

The compound functions as a bactericidal agent by interacting with the negatively charged bacterial cell wall. Contact of the cationic salt with the cell wall causes cytosolic leakage at low chlorohexidine HCl concentrations and cell lysis at higher concentrations. Duration of antibacterial effects has been shown to be enhanced by incorporating chlorhexidine HCl into human albumin microspheres. This lengthened antibacterial activity against Escheria coli, Staphylococcus aureus and Pseudomonas aeruginosa.

Product Specifications

Catalog ID C-725
CAS # 3697-42-5
MW 578.37 g/mol
UN Number 3077
Item Class 9
Group Number III
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C-725-5 5 g $ 53.00
C-725-25 25 g $ 192.00

Clotrimazole

Catalog ID Size Pricing
C-900-5 5 g $ 80.00
C-900-25 25 g $ 295.00
C-900-100 100 g $ 756.00

Description

Clotrimazole is an antifungal that targets the cell membrane of a variety of fungi including Candida and Aspergillus. It inhibits the synthesis of ergosterol causing an increase in cell membrane permeability. Additionally, clotrimazole is an activator of MB67 and inhibitor of CYP3A4 and CYP51A1.

Product Specifications

Catalog ID C-900
CAS # 23593-75-1
MW 344.84 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at 4°C. Protect from light.
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C-900-5 5 g $ 80.00
C-900-25 25 g $ 295.00
C-900-100 100 g $ 756.00

Cyclohex99

Catalog ID Size Pricing
C-931-1 1 g $ 60.00
C-931-5 5 x 1 g $ 165.00

Description

Cyclohex99 is the most pure form of cycloheximide available. It is over 98% pure and all toxic isomers have been removed. Cyclohex99 should be used for the most sensitive applications as it is free of impurities. In general, GoldBio’s Molecular Grade cycloheximide is suitable for most experiments.

Cycloheximide is a protein synthesis inhibitor in eukaryotic cells. It prevents ribosomal mRNA translocation during protein translation. Cycloheximide can be used to study cellular processes and inhibit yeast growth. It has also been used to determine half-life of a protein using western blotting techniques of protein cell lysate. Additionally, it has been used to select for CHX-resistant strains of yeast and fungi. It also displays neuroprotective properties.

Product Specifications

Catalog ID C-931
CAS # 66-81-9
MW 281.35 g/mol
UN Number 2811
Item Class 6.1
Group Number I
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C-931-1 1 g $ 60.00
C-931-5 5 x 1 g $ 165.00

Cycloheximide

Catalog ID Size Pricing
C-930-1 1 g $ 24.00
C-930-5 5 g $ 79.00
C-930-10 10 g $ 144.00
C-930-25 25 g $ 307.00

Description

Cycloheximide is a protein synthesis inhibitor in eukaryotic cells. It prevents ribosomal mRNA translocation during protein translation. Cycloheximide has a variety of applications. It can be used to study cellular processes and to determine the half-life of a protein using western blotting techniques of protein cell lysate. It has been used to select for CHX-resistant strains of yeast and fungi. It also displays neuroprotective properties. Additionally, Cycloheximide has been used to inhibit yeast growth at concentrations of 200μM. It has been used to promote production of ethylene in leaves and fruit.

Cycloheximide is reserved for in vitro applications due to its high toxicity.

Product Specifications

Catalog ID C-930
CAS # 66-81-9
MW 281.35 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at room temperature.
UN Number 2811
Item Class 6.1
Group Number I
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C-930-1 1 g $ 24.00
C-930-5 5 g $ 79.00
C-930-10 10 g $ 144.00
C-930-25 25 g $ 307.00

Dequalinium chloride

Catalog ID Size Pricing
D-190-250 250 mg $ 50.00
D-190-500 500 mg $ 80.00
D-190-1 1 g $ 125.00
D-190-2 2 g $ 180.00
D-190-5 5 g $ 351.00

Description

Dequalinium chloride is a quinolinium ion composed of symmetrical quaternary quinolinium units, one 4-amino-2-methylquinolin-1-yl group on each end of the molecule in place of a methyl hydrogen. It is a quaternary ammonium cation and forms an organic chloride salt. Its biological roles include antifungal agent and inhibitor of mitochondrial NADH ubiquione reductase. Medically, dequalinium chloride is the active ingredient of pharmaceuticals against bacterial infections and malaria; it has been applied as an antifungal, antinematadol and antiseptic drug.

Product Specifications

Catalog ID D-190
CAS # 522-51-0
MW 527.57 g/mol
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D-190-250 250 mg $ 50.00
D-190-500 500 mg $ 80.00
D-190-1 1 g $ 125.00
D-190-2 2 g $ 180.00
D-190-5 5 g $ 351.00

Econazole Nitrate

Catalog ID Size Pricing
E-200-5 5 g $ 62.00
E-200-25 25 g $ 223.00
E-200-100 100 g $ 585.00

Description

Econazole Nitrate is a broad-spectrum antimycotic imidazole antifungal targeting the cell membrane of fungi. It increases cell permeability via ergosterol synthesis inhibition. It is useful against fungi that cause Tinea especially Trichophyton and Microsporum species. It can be used to study platelet serotonin uptake and the synthesis of prostanoids.

Product Specifications

Catalog ID E-200
CAS # 24169-02-6
MW 444.70 g/mol
Grade MOLECULAR BIOLOGY GRADE
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E-200-5 5 g $ 62.00
E-200-25 25 g $ 223.00
E-200-100 100 g $ 585.00

Fluconazole

Catalog ID Size Pricing
F-450-100 100 mg $ 104.00

Description

Fluconazole is a fungistatic triazole antifungal targeting ergosterol synthesis leading to increased permeability of the fungal cell membrane. It is effective against Candida species, Cryptococcus species, neoformans, and dermatophytes. Fluconazole has been shown to down-regulate the metallothionein gene and inhibit CYP2C19, CYP2C9, and CYP3A4.

Product Specifications

Catalog ID F-450
CAS # 86386-73-4
MW 306.27 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at 4°C.
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F-450-100 100 mg $ 104.00

Griseofulvin

Catalog ID Size Pricing
G-650-5 5 g $ 49.00
G-650-25 25 g $ 179.00
G-650-50 50 g $ 338.00

Description

Griseofulvin is a fungistatic antifungal that targets microtubules. Isolated from Penicillium griseofulvum, Griseofulvin binds tubulin and interferes with mitosis and nucleic acid synthesis. It is effective against fungi causing tinea such as Microsporum, Epidermophyton, and Trichophyton. It has also been shown to promote apoptosis in in vitro studies of human tumor cell lines.

Product Specifications

Catalog ID G-650
CAS # 126-07-8
MW 352.77 g/mol
Grade MOLECULAR BIOLOGY GRADE
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G-650-5 5 g $ 49.00
G-650-25 25 g $ 179.00
G-650-50 50 g $ 338.00

Irgasan (Triclosan)

Catalog ID Size Pricing
I-660-25 25 g $ 107.00

Description

Irgasan (triclosan) is a broad-spectrum antifungal and antibiotic. It is often used as a supplement to cell culture media in Pseudomonas and Yersinia isolation agars to prevent bacterial contamination. It is slightly soluble in water and freely soluble in ethanol and methanol.

Irgasan binds the enoyl-acyl carrier protein reductase and forms a complex. Consequently, NAD (nicotinamide adenine dinucleotide) binds and prevents the enoyl-ACP complex from participating in the fatty acid synthesis cycle, suppressing bacterial cell growth.

Product Specifications

Catalog ID I-660
CAS # 3380-34-5
MW 289.54 g/mol
Grade MOLECULAR BIOLOGY GRADE
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I-660-25 25 g $ 107.00

Itraconazole

Catalog ID Size Pricing
I-670-100 100 mg $ 153.00
I-670-500 500 mg $ 522.00

Description

Itraconazole is a triazole antifungal agent used to increase fungal cell membrane permeability by inhibiting ergosterol synthesis, ultimately leading to fungal cell death. Itraconazole is effective against Blastomyces, Histoplasma, and Aspergillus species. It is used to study Candida infections in mice and to study proliferative changes in diabetic rats. Additionally, itraconazole is a hedgehog signaling inhibitor and CYP3A4 inhibitor.

Product Specifications

Catalog ID I-670
CAS # 84625-61-6
MW 705.63 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at 4°C.
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I-670-100 100 mg $ 153.00
I-670-500 500 mg $ 522.00

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