Anti-Fungal

Gold Biotechnology is committed to providing the best quality anti-fungal agents and fungicides for your laboratory research needs. Our antifungal reagents are perfectly suited for research in clinical microbiology, plant biology or mammalian cell culture. GoldBio antifungals are used in research and diagnostic applications in industry and academic research labs and have consistent lot-to-lot consistency to ensure the best research results and optimized efficiency.
Showing 1-20 of 25 items.

Validamycin A

Catalog ID Size Pricing
V-170-1 1 g $ 104.00

Description

Validamycin is a fungicidal, aminoglycoside antibiotic known to inhibit trehalases in plants, insects, and fungi as well as enhance trehalose accumulation in transgenic plants. It is effective against Pellicularia sasakii and Rhizoctonia solani in plants, but only decreases their virulence instead of exhibiting a fungicidal effect. In addition, validamycin is used to control sheath-blight disease in rice and is most effective against soil-borne pathogens. It is used to study trehalase activity and the synthesis of trehalose.

Product Specifications

Catalog ID V-170
CAS # 37248-47-8
MW 497.49 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store desiccated at -20°C.
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V-170-1 1 g $ 104.00

Caspofungin Acetate

Catalog ID Size Pricing
C-520-10 10 mg $ 130.00

Description

Caspofungin acetate is an echinocandin antifungal targeting the fungal cell membrane and inhibiting β(1,3)-D-Glucan synthase, a component necessary for cell wall synthesis. Caspofungin acetate is useful against Aspergillus and Candida species.

Product Specifications

Catalog ID C-520
CAS # 179463-17-3
MW 1213.42 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at -20°C.
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C-520-10 10 mg $ 130.00

Clotrimazole

Catalog ID Size Pricing
C-900-5 5 g $ 72.00
C-900-25 25 g $ 267.00
C-900-100 100 g $ 685.00

Description

Clotrimazole is an antifungal that targets the cell membrane of a variety of fungi including Candida and Aspergillus. It inhibits the synthesis of ergosterol causing an increase in cell membrane permeability. Additionally, clotrimazole is an activator of MB67 and inhibitor of CYP3A4 and CYP51A1.

Product Specifications

Catalog ID C-900
CAS # 23593-75-1
MW 344.84 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at 4°C. Protect from light.
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C-900-5 5 g $ 72.00
C-900-25 25 g $ 267.00
C-900-100 100 g $ 685.00

Econazole Nitrate

Catalog ID Size Pricing
E-200-5 5 g $ 56.00
E-200-25 25 g $ 201.00
E-200-100 100 g $ 530.00

Description

Econazole Nitrate is a broad-spectrum antimycotic imidazole antifungal targeting the cell membrane of fungi. It increases cell permeability via ergosterol synthesis inhibition. It is useful against fungi that cause Tinea especially Trichophyton and Microsporum species. It can be used to study platelet serotonin uptake and the synthesis of prostanoids.

Product Specifications

Catalog ID E-200
CAS # 24169-02-6
MW 444.70 g/mol
Grade MOLECULAR BIOLOGY GRADE
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E-200-5 5 g $ 56.00
E-200-25 25 g $ 201.00
E-200-100 100 g $ 530.00

Fluconazole

Catalog ID Size Pricing
F-450-100 100 mg $ 94.00

Description

Fluconazole is a fungistatic triazole antifungal targeting ergosterol synthesis leading to increased permeability of the fungal cell membrane. It is effective against Candida species, Cryptococcus species, neoformans, and dermatophytes. Fluconazole has been shown to down-regulate the metallothionein gene and inhibit CYP2C19, CYP2C9, and CYP3A4.

Product Specifications

Catalog ID F-450
CAS # 86386-73-4
MW 306.27 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at 4°C.
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F-450-100 100 mg $ 94.00

5-Fluorocytosine

Catalog ID Size Pricing
F-500-1 1 g $ 139.00
F-500-5 5 g $ 312.00

Description

5-Fluorocytosine is a fluorinated cytosine analog and antifungal agent. 5-fluorocytosine becomes 5-fluorouracil and is then incorporated into RNA, causing miscoding and inhibition of DNA synthesis. It is effective against Candida and Cryptococcus species and can be used as a negative selection agent in transgenic plants.

Product Specifications

Catalog ID F-500
CAS # 2022-85-7
MW 129.09 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at 4°C. Protect from light.
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F-500-1 1 g $ 139.00
F-500-5 5 g $ 312.00

Griseofulvin

Catalog ID Size Pricing
G-650-5 5 g $ 44.00
G-650-25 25 g $ 161.00
G-650-50 50 g $ 306.00

Description

Griseofulvin is a fungistatic antifungal that targets microtubules. Isolated from Penicillium griseofulvum, Griseofulvin binds tubulin and interferes with mitosis and nucleic acid synthesis. It is effective against fungi causing tinea such as Microsporum, Epidermophyton, and Trichophyton. It has also been shown to promote apoptosis in in vitro studies of human tumor cell lines.

Product Specifications

Catalog ID G-650
CAS # 126-07-8
MW 352.77 g/mol
Grade MOLECULAR BIOLOGY GRADE
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G-650-5 5 g $ 44.00
G-650-25 25 g $ 161.00
G-650-50 50 g $ 306.00

Itraconazole

Catalog ID Size Pricing
I-670-100 100 mg $ 139.00
I-670-500 500 mg $ 473.00

Description

Itraconazole is a triazole antifungal agent used to increase fungal cell membrane permeability by inhibiting ergosterol synthesis, ultimately leading to fungal cell death. Itraconazole is effective against Blastomyces, Histoplasma, and Aspergillus species. It is used to study Candida infections in mice and to study proliferative changes in diabetic rats. Additionally, itraconazole is a hedgehog signaling inhibitor and CYP3A4 inhibitor.

Product Specifications

Catalog ID I-670
CAS # 84625-61-6
MW 705.63 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at 4°C.
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I-670-100 100 mg $ 139.00
I-670-500 500 mg $ 473.00

Kasugamycin HCl

Catalog ID Size Pricing
K-200-1 1 g $ 63.00
K-200-10 10 g $ 278.00
K-200-50 50 g $ 947.00

Description

Kasugamycin HCl is an aminoglycoside antibiotic used to combat yeast and pathogenic fungi such as M. grisea. It has been isolated from Streptomyces kasugaensis. Kasugamycin has been used to prevent and treat M. grisea mycelia formation in rice and against parasitic infections of plants such as leaf spot or apple scab. It is the antibiotic of choice in many infections due to its low phytotoxicity. Additionally, kasugamycin has been used to study ribosome structure and kasugamycin resistance.

Product Specifications

Catalog ID K-200
CAS # 19408-46-9
MW 415.82 g/mol
Grade MOLECULAR BIOLOGY GRADE
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K-200-1 1 g $ 63.00
K-200-10 10 g $ 278.00
K-200-50 50 g $ 947.00

Natamycin

Catalog ID Size Pricing
N-600-50 50 mg $ 123.00
N-600-100 100 mg $ 159.00

Description

Natamycin is a macrolide polyene antifungal agent isolated from Streptomyces species. It is effective against fungi such as Candida, Aspergillus, Cephalosporium, Fusarium, and Penicillium. Natamycin works by binding ergosterol and preventing carbohydrate and amino acid transport. Unlike other polyene antifungals, natamycin does not prevent ergosterol synthesis or alter cell membrane permeability. Natamycin has been used to study the lipid bilayer and as a fungicidal agent in agar media. It has also been used in research on pleiotropic regulator AdpAch. It is sparingly soluble in aqueous solution.

Product Specifications

Catalog ID N-600
CAS # 7681-93-8
MW 665.73 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at 4°C. Protect from light.
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N-600-50 50 mg $ 123.00
N-600-100 100 mg $ 159.00

Nystatin

Catalog ID Size Pricing
N-750-250 250 g $ 408.00
N-750-500 500 g $ 691.00
N-750-1 1 kg $ 1,150.00
N-750-2.5 2.5 kg $ 2,375.00

Description

Nystatin is a fungicidal and fungistatic polyene antifungal targeting Candida species, especially those responsible for vaginal infections. It functions by inhibiting ergosterol synthesis and increasing cell membrane permeability, ultimately leading to fungal cell death. Nystatin has been used in combination with erythromycin and streptomycin in cell culture to eliminate fungal contamination.

Product Specifications

Catalog ID N-750
CAS # 1400-61-9
MW 926.09 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at -20°C.
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N-750-250 250 g $ 408.00
N-750-500 500 g $ 691.00
N-750-1 1 kg $ 1,150.00
N-750-2.5 2.5 kg $ 2,375.00

Cycloheximide

Catalog ID Size Pricing
C-930-1 1 g $ 21.00
C-930-5 5 g $ 73.00
C-930-10 10 g $ 133.00
C-930-25 25 g $ 271.00

Description

Cycloheximide is a protein synthesis inhibitor in eukaryotic cells. It prevents ribosomal mRNA translocation during protein translation. Cycloheximide has a variety of applications. It can be used to study cellular processes and to determine the half-life of a protein using western blotting techniques of protein cell lysate. It has been used to select for CHX-resistant strains of yeast and fungi. It also displays neuroprotective properties. Additionally, Cycloheximide has been used to inhibit yeast growth at concentrations of 200 μM. It has been used to promote production of ethylene in leaves and fruit.

Cycloheximide is reserved for in vitro applications due to its high toxicity.

Product Specifications

Catalog ID C-930
CAS # 66-81-9
MW 281.35 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at room temperature.
UN Number 2811
Item Class 6.1
Group Number I
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C-930-1 1 g $ 21.00
C-930-5 5 g $ 73.00
C-930-10 10 g $ 133.00
C-930-25 25 g $ 271.00

Cyclohex99

Catalog ID Size Pricing
C-931-1 1 g $ 54.00
C-931-5 1 x 5 g $ 149.00

Description

Cyclohex99 is the most pure form of cycloheximide available. It is over 98% pure and all toxic isomers have been removed. Cyclohex99 should be used for the most sensitive applications as it is free of impurities. In general, GoldBio’s Molecular Grade cycloheximide is suitable for most experiments.

Cycloheximide is a protein synthesis inhibitor in eukaryotic cells. It prevents ribosomal mRNA translocation during protein translation. Cycloheximide can be used to study cellular processes and inhibit yeast growth. It has also been used to determine half-life of a protein using western blotting techniques of protein cell lysate. Additionally, it has been used to select for CHX-resistant strains of yeast and fungi. It also displays neuroprotective properties.

Product Specifications

Catalog ID C-931
CAS # 66-81-9
MW 281.35 g/mol
UN Number 2811
Item Class 6.1
Group Number I
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C-931-1 1 g $ 54.00
C-931-5 1 x 5 g $ 149.00

Irgasan (Triclosan)

Catalog ID Size Pricing
I-660-25 25 g $ 99.00

Description

Irgasan (triclosan) is a broad-spectrum antifungal and antibiotic. It is often used as a supplement to cell culture media in Pseudomonas and Yersinia isolation agars to prevent bacterial contamination. It is slightly soluble in water and freely soluble in ethanol and methanol.

Irgasan binds the enoyl-acyl carrier protein reductase and forms a complex. Consequently, NAD (nicotinamide adenine dinucleotide) binds and prevents the enoyl-ACP complex from participating in the fatty acid synthesis cycle, suppressing bacterial cell growth.

Product Specifications

Catalog ID I-660
CAS # 3380-34-5
MW 289.54 g/mol
Grade MOLECULAR BIOLOGY GRADE
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I-660-25 25 g $ 99.00

Amphotericin B, USP Grade

Catalog ID Size Pricing
A-560-250 250 mg $ 49.00
A-560-500 500 mg $ 90.00
A-560-1 1 g $ 137.00
A-560-5 5 g $ 519.00

Description

Amphotericin B is a polyene antifungal isolated from Streptomyces species. While it has been suggested that Amphotericin B interacts with ergosterol of the fungal cell membrane leading to an altered cell membrane permeability and death, more recent studies show that the mechanism behind amphotericin B’s fungicidal activity is more complex. It is most effective against fungi and yeast and is often used against opportunistic fungal infections and leishmaniasis. Additionally, amphotericin B can be used to prevent growth of F. oxysporum in chickpea and P. triticina in wheat.

Product Specifications

Catalog ID A-560
CAS # 1397-89-3
MW 924.08 g/mol
Storage/Handling Store desiccated at 4°C. Protect from light.
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A-560-250 250 mg $ 49.00
A-560-500 500 mg $ 90.00
A-560-1 1 g $ 137.00
A-560-5 5 g $ 519.00

Amphotericin B, Solubilized

Catalog ID Size Pricing
A-561-250 250 mg $ 90.00
A-561-500 500 mg $ 173.00
A-561-1 1 g $ 321.00

Description

Solubilized amphotericin B is a mixture of 45% amphotericin B, 35% sodium deoxycholate, and 10% phosphate buffer. It is completely soluble in aqueous solution.

Amphotericin B is a polyene antifungal isolated from Streptomyces species. While it has been suggested that Amphotericin B interacts with ergosterol of the fungal cell membrane leading to an altered cell membrane permeability and death, more recent studies show that the mechanism behind amphotericin B’s fungicidal activity is more complex. It is most effective against fungi and yeast and is often used against opportunistic fungal infections and leishmaniasis. Additionally, amphotericin B can be used to prevent growth of F. oxysporum in chickpea and P. triticina in wheat.

Product Specifications

Catalog ID A-561
CAS # 1397-89-3
MW 924.08 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at 4°C.
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A-561-250 250 mg $ 90.00
A-561-500 500 mg $ 173.00
A-561-1 1 g $ 321.00

Ampho99

Catalog ID Size Pricing
A-562-250 250 mg $ 52.00
A-562-500 500 mg $ 94.00
A-562-1 1 g $ 166.00

Description

Ampho99 is the purest form of amphotericin B available and should be used for the most sensitive applications. In general, GoldBio’s USP Grade amphotericin B will not adversely affect your cells and is suitable for most experiments.

Amphotericin B is a polyene antifungal isolated from Streptomyces species. While it has been suggested that Amphotericin B interacts with ergosterol of the fungal cell membrane leading to an altered cell membrane permeability and death, more recent studies show that the mechanism behind amphotericin B’s fungicidal activity is more complex. It is most effective against fungi and yeast and is often used against opportunistic fungal infections and leishmaniasis. Additionally, amphotericin B can be used to prevent growth of F. oxysporum in chickpea and P. triticina in wheat. It is soluble in acidic and basic conditions.

Product Specifications

Catalog ID A-562
CAS # 1397-89-3
MW 924.08 g/mol
Storage/Handling Store at 4°C.
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A-562-250 250 mg $ 52.00
A-562-500 500 mg $ 94.00
A-562-1 1 g $ 166.00

Miconazole Nitrate

Catalog ID Size Pricing
M-860-5 5 g $ 161.00

Description

Miconazole Nitrate is an imidazole antifungal targeting fungi responsible for causing tinea, especially Trichophyton species. It is an ergosterol synthesis inhibitor, which ultimately increases cell membrane permeability and causes fungal cell death. Miconazole nitrate inhibits platelet cyclooxygenase and induces reactive oxygen species in fungal biofilms. Additionally, it has been used to study automated luminescence-based cytochrome P450 profiling.

Product Specifications

Catalog ID M-860
CAS # 22832-87-7
MW 479.14 g/mol
Grade MOLECULAR BIOLOGY GRADE
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M-860-5 5 g $ 161.00

Cetylpyridinium chloride

Catalog ID Size Pricing
C-120-100 100 g $ 47.00

Description

No description available

Product Specifications

Catalog ID C-120
CAS # 6004-24-6
MW 358.00 g/mol
UN Number 2811
Item Class 6.1
Group Number II
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C-120-100 100 g $ 47.00

Chlorhexidine

Catalog ID Size Pricing
C-615-1 1 g $ 84.00
C-615-5 5 g $ 334.00

Description

No description available

Product Specifications

Catalog ID C-615
CAS # 55-56-1
MW 505.45 g/mol
UN Number 3077
Item Class 9
Group Number III
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C-615-1 1 g $ 84.00
C-615-5 5 g $ 334.00

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