Pharmaceutical Intermediates

5-Methoxy-L-tryptophan is a tryptophan derivative.

5-Methoxyindole Ultra Pure is used to synthesize and analyze interactions between indole species. It displays dual agonist and inverse agonist activity at the 5-HT_3B receptor and partial agonism at the 5-HT_3A receptor.

5-Methyl-DL-tryptophan is an analog of tryptophan. It is an inhibitor of anthranilate compound synthesis. Additionally, 5-methyl-DL-tryptophan is used to select for genetic mutants of Methanococcus voltae. It is a repressor of the Trp operon and a tryptophanase substrate as well.

5-Nitro-DL-tryptophan is a tryptophan derivative commonly used in biochemical research applications.

5-Nitroindole is a reagent involved in the synthesis of a variety of biochemical compounds, including: 2-oxo-1-pyrrolidine analogs, mGlu4 allosteric modulators, protein kinase inhibitors, antiproliferative agents, anti-HIV 1 agents, antifungal agents, anti-leukemic agents, antivascular agents, anticancer agents, and cannabinoid receptor type 1 (CB1) antagonists.

6-Aminopenicillanic acid (6-APA) is the central component of penicillin β-lactam antibiotics which are generated by Penicillium. 6-APA forms from penicillin G after being catalyzed by penicillin acylases. This compound can be used to create semi-synthetic antibiotics that are effective against non-penicillinase forming bacterium, such as Streptococcus and some Staphylococcus.

6-APA is used as precursor for antibiotic compounds ampicillin and amoxicillin. Antibiotic synthesis of 6-APA can be augmented with a supersaturated solution of nucleophiles. Other methods for enhancing effectiveness involves diminishing ionic strength in a reaction mixture along with the addition of 2-butanol. Implementing a pH gradient starting at pH 7 and reducing the pH to 6.5 near reaction completion can greatly increase reaction output.

6-Aminoquinolyl-N-hydroxysuccinimidyl carbamate is used to detect proteins and amino acids. It reacts with amino acids forming stable unsymmetrical urea derivatives. It can be used with HPLC analysis.

6-Bromo-DL-tryptophan is an analog of tryptophan.

6-Chloro-3-indoxyl-alpha-D-mannopyranoside is a chromogenic substrate for α-mannosidase, which yields a salmon colored precipitate upon cleavage.

6-Chloro-3-indoxyl-beta-D-glucuronic acid, cyclohexylammonium salt is a chromogenic β-glucuronidase substrate, which yields a salmon colored precipitate upon cleavage.

6-Chloro-DL-tryptophan is a reagent used for chemical synthesis.

6-Dimethylamino-9-(b-D-ribofuranosyl)purine is a methyladenosine compound functioning as a heterocyclic building block and reagent in nucleotide chemistry. It’s composed of two methyl groups bound to an adenine nucleobase. 6-Dimethylamino-9-(b-D-ribofuranosyl)purine has roles in nucleic composition. Modified with fatty acids, the molecule has been shown to be effective against tumor activity in cultured L1210 leukemia and Ehrlich ascites.

The tertiary amino compound is a minor rRNA nucleoside responsible for structure. Antibodies to 6-Dimethylamino-9-(b-D-ribofuranosyl)purine located the nucleoside in bacterial ribosomes, placing it at the 30S subunit of E. coli near the 3’ end; it is not present in kasugamycon-resistant mutants. In peas, chromatographic tests confirmed conservation in chloroplast rRNA subunits analogous to those in E. coli. Residues of this substance were likewise present in wheat germ at the small 18S and 40S RNA subunit particles. It’s been located in the tRNA of Mycobacterium bovis Bacille Calmette-Guérin (BCG) as well.

6-Hydroxyindole is used in the preparation of a variety of biochemical compounds, including: tryptophan dioxygenase inhibitors, anti-tuberculosis agents, HIV inhibitors, anticancer agents, tubulin polymerization inhibitors, and notoamide J.

6-Methoxyindole reactant used in the synthesis of tryptophan dioxygenase inhibitors, antitumor agents, T cell kinase inhibitors, VEGFR-2 inhibitors, and HIV-1 inhibitors. Additionally, it is used to study protonated, excited-state forms of serotonin and inhibits myeloperoxidase.

6-Methyl-DL-tryptophan is an analog of tryptophan.

7-Methoxyindole is a reagent used in the preparation of tryptophan dioxygenase inhibitors, indolylindazoles and indolylpyrazolopyridines, HIV-1 inhibitors, and histone deacetylase inhibitors. Additionally, it is used to study how methoxy and amino substitutions affect indole rings and has been shown to inhibit the growth of tobacco cells.

7-Methyl-DL-tryptophan is a tryptophan analog.

Adenosine is an endogenous nucleoside (comprising a molecule of adenine attached to a ribose sugar molecule) and neurotransmitter that can act as the preferred agonist at adenosine A receptor subtypes. The function of adenosine is primarily for cytoprotection and for preventing tissue damage in response to stress or injury.