Anti-Cancer

Gold Biotechnology is committed to carrying only the highest grade anti-cancer or chemotherapeutic products for the cancer research field. Our cancer research reagents include apoptosis inducers, antitumor antimicrobials, growth factor inhibitors, drug precursors, dyes and stains. GoldBio provides the best quality cancer research reagents so that you can develop the best chemotherapeutic research strategies.
Showing 1-20 of 66 items.

Rapamycin

Catalog ID Size Pricing
R-101-100 100 mg $ 229.00
R-101-500 500 mg $ 899.00

Description

Rapamycin is a macrolide antibiotic isolated from Streptomyces hygroscopicus. It has been shown to display anticancer activity such as induction of apoptosis and inhibition of angiogenesis and proliferation in tumor cell lines. Rapamycin is also an immunosuppressant and FRAP inhibitor and inhibits lymphokine-induced cell proliferation.

Product Specifications

Catalog ID R-101
CAS # 53123-88-9
MW 914.17 g/mol
Storage/Handling Store at room temperature.
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R-101-100 100 mg $ 229.00
R-101-500 500 mg $ 899.00

Amygdalin

Catalog ID Size Pricing
A-570-100 100 g $ 151.00
A-570-250 250 g $ 275.00
A-570-500 500 g $ 441.00
A-570-1000 1 kg $ 816.00

Description

Amygdalin is a glucoside derived from almonds and apricot kernels. While it was originally suggested that amygdalin is an anticancer agent, it is avoided due to its cyanogenic properties. Upon being metabolized by β-glucosidase enzymes, amygdalin produces hydrogen cyanide, which is cytotoxic on tumor cells. Amygdalin is freely soluble in aqueous solution and is used to study cytotoxic effects of cyanide on cancer cells and can be useful in identification and analysis of maltases, emulsins, and β-glucosidases.

Product Specifications

Catalog ID A-570
CAS # 29883-15-6
MW 457.43 g/mol
Grade MOLECULAR BIOLOGY GRADE
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A-570-100 100 g $ 151.00
A-570-250 250 g $ 275.00
A-570-500 500 g $ 441.00
A-570-1000 1 kg $ 816.00

Brefeldin A

Catalog ID Size Pricing
B-930-5 5 mg $ 94.00
B-930-50 50 mg $ 344.00

Description

Brefeldin A is an antibiotic derived from Penicillium brefeldianum. It is an anti-cancer agent which disrupts protein transport and causes apoptosis of tumor cells. Brefeldin A disrupts the function of the Golgi apparatus and blocks Golgi-COPI activity. ER vesicles are prevented from fusion with the Golgi and are secretion is inhibited. Additionally, Brefeldin A is an ARF inhibitor, sphingomyelin cycle activator, and caspase-3 activator. It has been shown to induce apoptosis in leukemia cells and colon cancer cells.

Product Specifications

Catalog ID B-930
CAS # 20350-15-6
MW 280.36 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at 4°C.
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B-930-5 5 mg $ 94.00
B-930-50 50 mg $ 344.00

Cyclosporin A

Catalog ID Size Pricing
C-940-100 100 mg $ 58.00
C-940-500 500 mg $ 217.00

Description

The cyclosporins are a group of macrolide immunosuppressants isolated from fungi. They are researched for their use in prevention of post-transplant graft rejection. Their mechanism of action involves suppression of cytotoxic T-cell maturation and activity by binding lymphocyte protein cyclophilin. Cyclophilin and cyclosporin form a complex targeting calcineurin, which is responsible for activating T-lymphocytes. Additionally, the cyclosporins are researched for their ability to prevent damage to normal functioning cells in autoimmune disorders.


Cyclosporin A is over 99% pure and soluble in DMSO and ethyl alcohol.

Product Specifications

Catalog ID C-940
CAS # 59865-13-3
MW 1202.61 g/mol
Storage/Handling Store at 4°C.
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C-940-100 100 mg $ 58.00
C-940-500 500 mg $ 217.00

Doxorubicin HCl, USP Grade

Catalog ID Size Pricing
D-490-100 100 mg $ 59.00
D-490-500 500 mg $ 138.00
D-490-1 1 g $ 239.00

Description

Doxorubicin HCl is an anthracycline antibiotic that inhibits cancer progression by suppressing DNA replication. It is the 12-hydroxylated form of daunorubicin and causes DNA intercalation. It also inhibits topoisomerase II. Doxorubicin is researched for its efficacy against non-Hodgkin’s lymphoma, multiple myeloma, acute leukemias, Kaposi sarcoma, Wilm tumor, Ewing sarcoma, and cancers of the breast, lung, ovary, endometrium, and adrenal cortex. Doxorubicin is an MRP-1 substrate and has been used in drug-resistance studies.

Product Specifications

Catalog ID D-490
CAS # 25316-40-9
MW 579.98 g/mol
Storage/Handling Store at 4°C. Protect from light.
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D-490-100 100 mg $ 59.00
D-490-500 500 mg $ 138.00
D-490-1 1 g $ 239.00

10-Deacetyl Baccatin III

Catalog ID Size Pricing
D-550-5 5 mg $ 183.00
D-550-25 25 mg $ 689.00

Description

10-Deacetyl baccatin III is an intermediate in the synthesis of the chemotherapeutic drug, paclitaxel (taxol). It is produced by and isolated from Taxus baccata. 10-Deacetyl baccatin III is an immiscible organic compound.

Product Specifications

Catalog ID D-550
CAS # 32981-86-5
MW 544.59 g/mol
Grade MOLECULAR BIOLOGY GRADE
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D-550-5 5 mg $ 183.00
D-550-25 25 mg $ 689.00

Epibrassinolide

Catalog ID Size Pricing
E-250-10 10 mg $ 52.00
E-250-100 100 mg $ 190.00
E-250-25 25 mg $ 74.00
E-250-50 50 mg $ 111.00

Description

Epibrassinolide is a plant steroid hormone of the brassinosteroid family. Its functions include protection from environmental stressors and altering the metabolism under a variety of conditions. Epibrassinolide has been shown to decrease toxicity and stimulate healthy plant growth in plants under stress.

Product Specifications

Catalog ID E-250
CAS # 78821-43-9
MW 480.68 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at -20°C.
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E-250-10 10 mg $ 52.00
E-250-100 100 mg $ 190.00
E-250-25 25 mg $ 74.00
E-250-50 50 mg $ 111.00

Erlotinib HCl

Catalog ID Size Pricing
E-270-100 100 mg $ 94.00
E-270-1 1 g $ 317.00

Description

Erlotinib HCl is an anti-cancer agent targeting epidermal growth factor receptor (EGFR) tyrosine kinase ATP binding sites, which are commonly overexpressed and sometimes mutated in a variety of cancers. Erlotinib prevents the formation of EGFR homodimers leading to suppression of signal transmittance and tumor growth inhibition. Additionally, erlotinib suppresses cyclin-dependent kinase 2 (Cdk2). It has been shown to be effective against non-small cell lung cancer and pancreatic cancer.

Product Specifications

Catalog ID E-270
CAS # 183321-74-6
MW 393.44 g/mol
Grade MOLECULAR BIOLOGY GRADE
UN Number 3077
Item Class 9
Group Number III
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E-270-100 100 mg $ 94.00
E-270-1 1 g $ 317.00

Gefitinib

Catalog ID Size Pricing
G-610-100 100 mg $ 52.00
G-610-1 1 g $ 167.00
G-610-5 5 g $ 306.00

Description

Gefitinib is an anti-cancer agent similar to erlotinib. It functions through inhibiting the overexpressed or mutated epidermal growth factor receptor (EGFR) by binding its ATP binding site. Overexpression and mutation of EGFR are common in cancer cell lines and may lead to uncontrolled proliferation through the Ras signaling cascade. Gefitinib has been shown to induce tumor cell apoptosis in HaCaT cells, KG-1 cells, P39 cells, and CD34+ myeloblasts. Additionally, it has been shown to promote keratinocyte apoptosis.

Product Specifications

Catalog ID G-610
CAS # 184475-35-2
MW 446.90 g/mol
Grade MOLECULAR BIOLOGY GRADE
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G-610-100 100 mg $ 52.00
G-610-1 1 g $ 167.00
G-610-5 5 g $ 306.00

Mitoxantrone HCl

Catalog ID Size Pricing
M-910-50 50 mg $ 111.00

Description

Mitoxantrone HCl is an anthracenedione anti-cancer agent. It functions by intercalating between DNA and causing double-stranded breaks. This inhibits T-cell, B-cell, and macrophage division and prevents DNA repair and synthesis. It has been shown to be effective against breast cancers, leukemias, and non-Hodgkin’s lymphoma. It also exhibits immunosuppressive activity by inducing apoptosis in antigen-presenting T-cells and is an immune system regulator in multiple sclerosis.

Product Specifications

Catalog ID M-910
CAS # 70476-82-3
MW 517.40 g/mol
Grade MOLECULAR BIOLOGY GRADE
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M-910-50 50 mg $ 111.00

Nicotinamide (Vitamin B3), USP Grade

Catalog ID Size Pricing
N-640-500 500 g $ 104.00

Description

Nicotinamide is a metabolized amide form of vitamin B3. It is an anti-cancer agent and inhibitor of PARP-1, which is responsible for repairing DNA damage caused by chemotherapy. Nicotinamide is converted to nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) for use in biological redox reactions. Additionally, nicotinamide is a nicotinamide phosphoribosyltransferase (NAMPT) substrate and anti-inflammatory agent.

Product Specifications

Catalog ID N-640
CAS # 98-92-0
MW 122.12 g/mol
Storage/Handling Store at 4°C.
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N-640-500 500 g $ 104.00

Thiostrepton

Catalog ID Size Pricing
T-300-1 1 g $ 89.00
T-300-5 5 g $ 342.00

Description

Thiostrepton is a cyclic peptide antibiotic isolated from Streptomyces azureus. It targets a wide variety of gram-negative and gram-positive bacteria, especially those causing skin infections. It has been used as a marker for selection of recombinant Streptomyces cultures. Additionally, thiostrepton has been shown to inhibit FOXM1, a gene commonly overexpressed in cancer cell lines, thus inhibiting cancer cell growth.

Thiostrepton functions by binding elongation factor G (EF-G) and interfering with ribosomal GTPase activity, ultimately inhibiting protein synthesis.

Product Specifications

Catalog ID T-300
CAS # 1393-48-2
MW 1664.89 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at -20°C.
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T-300-1 1 g $ 89.00
T-300-5 5 g $ 342.00

Thiostrep99

Catalog ID Size Pricing
T-301-1 1 g $ 92.00
T-301-5 5 g $ 361.00

Description

Thiostrep99 is the most pure form of thiostrepton available. It is over 98% pure and should be used for the most sensitive applications and on the most sensitive cell lines since any impurities that might cause inhibition of resistant cell lines have been removed. In general, our Molecular Grade thiostrepton will not adversely affect your cells and is suitable for most experiments.

Product Specifications

Catalog ID T-301
CAS # 1393-48-2
MW 1664.89 g/mol
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T-301-1 1 g $ 92.00
T-301-5 5 g $ 361.00

Colchicine

Catalog ID Size Pricing
C-910-500 500 mg $ 64.00
C-910-1 1 g $ 84.00

Description

Colchicine is an alkaloid isolated from Colchicum autumnale and other Colchica species. It is an antimitotic agent useful against various cancer cell lines. Colchicine disrupts microtubules and can be used to induce tetraploidy in plant cells. It is an activator of the JNK/SAPK signaling pathway and used to select for cells containing MDCK (NBL-2) resistance. Colchicine’s antimitotic properties are more effective against cancer cells due to their increased mitotic rate compared to that of healthy cells. Colchicine is useful in cell division studies.

Product Specifications

Catalog ID C-910
CAS # 64-86-8
MW 399.44 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at 4°C.
UN Number 1544
Item Class 6.1
Group Number I
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C-910-500 500 mg $ 64.00
C-910-1 1 g $ 84.00

Mitomycin C, USP Grade

Catalog ID Size Pricing
M-900-25 25 mg $ 53.00
M-900-100 100 mg $ 153.00
M-900-500 500 mg $ 509.00
M-900-1 1 mg $ 815.00

Description

Mitomycin C is an antineoplastic antibiotic isolated from Streptomyces caespitosus. It is effective against gram-negative and gram-positive bacteria and a variety of cancer cells, including Ehrlich ascites tumor cells. Mitomycin C has been used to produce mitotically inactivated feeder cells and has been shown to increase recombination during fruit fly meiosis. It is capable of killing mutant strains of Arabidopsis that are defective for recombination during meiosis.

Mitomycin C functions as a DNA crosslinking agent, inhibiting DNA synthesis.

Product Specifications

Catalog ID M-900
CAS # 50-07-7
MW 334.33 g/mol
Storage/Handling Store at 4°C.
UN Number 2811
Item Class 6.1
Group Number II
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M-900-25 25 mg $ 53.00
M-900-100 100 mg $ 153.00
M-900-500 500 mg $ 509.00
M-900-1 1 mg $ 815.00

Streptozocin

Catalog ID Size Pricing
S-480-100 100 mg $ 46.00
S-480-1 1 g $ 107.00

Description

Streptozocin is an anti-tumor agent reserved as a last resort against metastatic pancreatic islet cells. Streptozocin functions by adding methyl and alkyl groups to DNA and interfering with normal base pairing. This damages the DNA and causes a decrease in tumor size. Streptozocin enters cells via the glucose transport protein, GLUT2. It is capable of causing vasorelaxation, NCOAT inhibition, and donating nitric oxide (NO).

Product Specifications

Catalog ID S-480
CAS # 18883-66-4
MW 265.22 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store desiccated at -20°C.
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S-480-100 100 mg $ 46.00
S-480-1 1 g $ 107.00

Cyclosporin B

Catalog ID Size Pricing
C-942-5 5 mg $ 191.00

Description

The cyclosporins are a group of macrolide immunosuppressants isolated from fungi. They are researched for their use in prevention of post-transplant graft rejection. Their mechanism of action involves suppression of cytotoxic T-cell maturation and activity by binding lymphocyte protein cyclophilin. Cyclophilin and cyclosporin form a complex targeting calcineurin, which is responsible for activating T-lymphocytes. Additionally, the cyclosporins are researched for their ability to prevent damage to normal functioning cells in autoimmune disorders.


Cyclosporin B is soluble in DMSO and ethyl alcohol.

Product Specifications

Catalog ID C-942
CAS # 63775-95-1
MW 1188.58 g/mol
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C-942-5 5 mg $ 191.00

Bleomycin Sulfate, USP Grade

Catalog ID Size Pricing
B-910-10 10 mg $ 122.00
B-910-50 50 mg $ 423.00

Description

Bleomycin Sulfate is an anti-cancer agent isolated from Streptomyces verticillus. Bleomycin is a mixture of bleomycin A2 and bleomycin B2, in an approximately 2:1 ratio, respectively. However, the ratio varies by lot number.

Bleomycin is used against Hodgkin’s lymphoma. Its mechanism is not well understood; however, it is though that bleomycin chelates metallic ions causing a decrease in enzyme stability. The enzymes react with oxygen and produce free radicals, ultimately causing single-stranded breaks in deoxyribose sugars of DNA.

Product Specifications

Catalog ID B-910
CAS # 9041-93-4
MW 1512.62 g/mol
Storage/Handling Store desiccated at 4°C.
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B-910-10 10 mg $ 122.00
B-910-50 50 mg $ 423.00

Cyclosporin D

Catalog ID Size Pricing
C-944-5 5 mg $ 294.00

Description

The cyclosporins are a group of macrolide immunosuppressants isolated from fungi. They are researched for their use in prevention of post-transplant graft rejection. Their mechanism of action involves suppression of cytotoxic T-cell maturation and activity by binding lymphocyte protein cyclophilin. Cyclophilin and cyclosporin form a complex targeting calcineurin, which is responsible for activating T-lymphocytes. Additionally, the cyclosporins are researched for their ability to prevent damage to normal functioning cells in autoimmune disorders.


Cyclosporin D is soluble in DMSO and ethyl alcohol.

Product Specifications

Catalog ID C-944
CAS # 63775-96-2
MW 1216.64 g/mol
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C-944-5 5 mg $ 294.00

Methotrexate Sodium Salt

Catalog ID Size Pricing
M-980-250 250 mg $ 98.00

Description

Methotrexate sodium salt is an anti-cancer agent that works by inhibiting folic acid metabolism. Methotrexate is an allosteric dihydrofolate reductase (DHFR) inhibitor. DHFR is is an essential enzyme in folic acid metabolism. Folic acid is necessary for production of thymidine and purine; therefore, methotrexate is a nucleic acid synthesis inhibitor. It is freely soluble in aqueous solution.

Product Specifications

Catalog ID M-980
CAS # 7413-34-5
MW 498.40 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store desiccated at 4°C. Protect from light.
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M-980-250 250 mg $ 98.00

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